1 2 Sodium butyrate stimulates NHE 8 expression via its role on 3 activating NHE 8 basal promoter activity 4 5 6
نویسندگان
چکیده
Fayez K. Ghishan, M.D. 17 Department of Pediatrics 18 Steele Children’s Research Center 19 1501 N. Campbell Ave. 20 Tucson, AZ 85724 21 Phone: (520) 626-5170 22 Fax: (520) 626-4141 23 Email: [email protected] 24 25 26 27 28 29
منابع مشابه
Apical NHE isoforms differentially regulate butyrate-stimulated Na absorption in rat distal colon.
Bicarbonate and butyrate stimulate electroneutral Na absorption via apical membrane Na-H exchange (NHE) in rat distal colon. cAMP downregulates NHE-3 isoform and inhibits HCO3-dependent, but not butyrate-dependent, Na absorption. This study sought to determine whether 1) the apical membrane NHE-2 and NHE-3 isoforms differentially mediated HCO3- and butyrate-dependent Na absorption, and 2) cAMP ...
متن کاملGb regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development
Li, Xiao Xi, Frederick E. Albrecht, Jean E. Robillard, Gilbert M. Eisner, and Pedro A. Jose. Gb regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development. Am J Physiol Regulatory Integrative Comp Physiol 278: R931–R936, 2000.—The decreased natriuretic action of dopamine in the young has been attributed to decreased generation of cAMP by the activated renal D1-like...
متن کاملGbeta regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development.
The decreased natriuretic action of dopamine in the young has been attributed to decreased generation of cAMP by the activated renal D(1)-like receptor. However, sodium/hydrogen exchanger (NHE) 3 activity in renal brush-border membrane vesicles (BBMV) can be modulated independent of cytoplasmic second messengers. We therefore studied D(1)-like receptor regulation of NHE activity in BBMVs in 2-,...
متن کاملDifferential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum.
Electroneutral Na absorption occurs in the intestine via sodium-hydrogen exchanger (NHE) isoforms NHE2 and NHE3. Bicarbonate and butyrate both stimulate electroneutral Na absorption through NHE. Bicarbonate- but not butyrate-dependent Na absorption is inhibited by cholera toxin (CT). Long-term exposure to butyrate also influences expression of apical membrane proteins in epithelial cells. These...
متن کاملSubcloning, localization, and expression of the rat intestinal sodium-hydrogen exchanger isoform 8.
Apically expressed intestinal and renal sodium-hydrogen exchangers (NHEs) play a major role in Na(+) absorption. Our previous studies on NHE ontogeny have shown that NHE-2 and NHE-3 are expressed at very low levels in young animals. Furthermore, single and/or double NHE-2 and NHE-3 knockout mice display no obvious abnormalities before weaning. These observations suggest that other transporter(s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015